Saypro Spermicides (used Alone Or With The Cervical Cap, Diaphragm Or Sponge). Spermicides That Have Nonoxynol-9 Can Irritate The Vagina. This Can Raise Your Risk For Getting Hiv. Use Spermicides With Nonoxynol-9 Only If You Are In A Monogamous Relationship (you Have Sex Only With Each Other) With A Man You Know Is Hiv-negative. Also, Medicines For Vaginal Yeast Infections May Make Spermicides Less Effective.